Endocrine Abstracts

Chemerin is a newly discovered chemoattractant adipokine and is a natural ligand for the G protein coupled receptor CMKLR1. Its role in the regulation of energy metabolism and inflammation makes it a promising candidate for urgently needed pharmacological treatment strategies for obesity. To demonstrate a central role of chemerin, we manipulated chemerin signalling in the arcuate nucleus, a specific hypothalamic region associated with appetite regulation. We designed a short-h...